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The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets

✍ Scribed by N. Sasaki; M. Iwase; Y. Uchizono; U. Nakamura; H. Imoto; S. Abe; M. Iida

Publisher
Springer
Year
2006
Tongue
English
Weight
275 KB
Volume
49
Category
Article
ISSN
0012-186X

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Abnormal insulin secretion and glucose m
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Insulin secretion and islet glucose metabolism were compared in pancreatic islets isolated from GK/Wistar (GK) rats with spontaneous Type 2 (non-insulin-dependent) diabetes mellitus and control Wistar rats. Islet insulin content was 24.5 +/- 3.1 microU/ng islet DNA in GK rats and 28.8 +/- 2.5 microU