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The ATM gene and breast cancer: is it really a risk factor?

✍ Scribed by Sandra Angèle; Janet Hall

Book ID
117768046
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
110 KB
Volume
462
Category
Article
ISSN
1383-5742

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## Abstract Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of the disease. A 1100delC mutation in CHEK2 (previously known as CHK2), a cell‐cycle checkpoint kinase, has been implicated in predi