The asymmetric synthesis of (−)-captopril utilising the iron chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)]
✍ Scribed by George Bashiardes; Stephen G. Davies
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 143 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Treatment of the lithium enolate derived from homochiral S-](qS-CSHS)Fe(CO)(PPh3)COCH2CH3] with homochiral R-or S-propylene oxide or R-styrene oxide in the presence of diethylaluminium chloride followed by oxidative decomplexation generated cis-2S,4R-dimethyl butyrolactone, trans-2S,4S-dimethyl buty
Michael addition of lithium benzylamide to the enantiomerically pure (S)-E-crotonyl complex of C(~5-C,H,)Fe(CO)(PPh~)l followed by trapping of the resultant enolate with methyl iodide or methanol occurs with high diastereoselectivity and gives after decomplexation the essentially optically pure (3R)