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The Asymmetric Catalytic Aldol Reaction of Allenolates with Aldehydes Using N -Fluoroacyl Oxazaborolidine as the Catalyst

✍ Scribed by Li, Guigen; Wei, Han-Xun; Phelps, Brian S.; Purkiss, David W.; Kim, Sun Hee


Book ID
119979187
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
62 KB
Volume
3
Category
Article
ISSN
1523-7060

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The Aldol Reaction of Allenolates with A
✍ Guang-Hui Deng; Hui Hu; Han-Xun Wei; Paulβ€…W. ParΓ© πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 82 KB

## Abstract Stereoselective synthesis of (__Z__)‐__Ξ±__‐(hydroxyalkyl)‐__Ξ²__‐iodoacrylates (=(2__Z__)‐2‐(hydroxyalkyl)‐3‐iodoprop‐2‐enoates) was achieved in a one‐pot coupling reaction from methyl prop‐2‐ynoate, Me~3~SiI, and an alkanal under mild conditions with MgI~2~ as catalyst (β†’ **1**–**9**; s