The astrocytic (“peripheral-type”) benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy
✍ Scribed by Roger F Butterworth
- Book ID
- 117410529
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 305 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0197-0186
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In mammalian brain peripheral benzodiazepine (PBZD) receptors are predominantly localized on astroglial cells. Previous studies utilizing whole membrane preparations from brain and peripheral organs of various species have indicated several distinctions between the drug-receptor interactions of the
## Abstract Astrocytes synthesize a series of regulatory peptides called endozepines, which act as endogenous ligands of benzodiazepine receptors. We have recently shown that one of these endozepines, the triakontatetraneuropeptide TTN, stimulates DNA synthesis in astroglial cells. The purpose of t