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The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis

✍ Scribed by Niels A. Graudal; Hans O. Madsen; Ulrik Tarp; Arne Svejgaard; Anne Grethe Jurik; Hans K. Graudal; Peter Garred

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 181 KB
Volume: 43
Category: Article
ISSN: 0004-3591
DOI: 10.1002/1529-0131(200003)43:3<515::aid-anr6>3.0.co;2-t

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Objective. Patients with rheumatoid arthritis (RA) have excess morbidity and mortality due to ischemic heart disease. It has been suggested that high serum levels of mannose-binding lectin (MBL) and agalactosyl IgG (IgG-G0) are associated with increased inflammation in RA. MBL also enhances inflamma

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## Abstract ## Objective To determine whether the HLA–DRB1 shared epitope (SE) is associated with early mortality and specific causes of death in rheumatoid arthritis (RA). ## Methods HLA–DRB1 genotyping was carried out on blood samples from 767 patients recruited for the Early RA Study (ERAS),