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The association of the short variant of the 5-HTTPLR polymorphism and the apoE4 allele does not increase the risk for late onset Alzheimer’s disease

✍ Scribed by Oliveira, J R M; Shimokomaki, C M; Brito-Marques, P R; Gallindo, R M; Okuma, M; Maia, L G S; Otto, P A; Passos-Bueno, M R; Zatz, M

Book ID
110058995
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
27 KB
Volume
4
Category
Article
ISSN
1359-4184

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It was suggested that in contrast to the E4 allele, the E2 allele of the apolipoprotein E gene (APOE"2) has a protective effect for late-onset Alzheimer's disease and early-onset Alzheimer's disease (EOAD). We studied the role of the APOE\*2 allele in the pathogenesis of EOAD in a Dutch population-b