cthylnminc (nn activo principle of ergot) rcsults in n loss of nctivity. Tho introduction of tho ncctyl group into tho cholino rnolccule convcrts this conipnptivcly inert substnnco into n powcrful hcnrt poison. Highly intcrcsting is tho cnso of nconitino. This intcnscly poiso!ious nlknloid is tho ncotyl dcrivntirc of bcnznconInc, tho lnttcr substnncc k111g rclntivclp non-tosic. Yct tho introduction of furthor ncctyl groups into tho nconitino molcculo docs not incrcnso, but diminishes, its toxicity.
Considering syntliotic drugs from tho point of view of tlicir innnufnctiiro, \vo find t h a t in vory mnny of tlicni alcoliol is ncccssnry, cithcr ns I L solront or ns n rcscting constitucnt-e.g., ndrilin, anresthcsin, plicnnzonc, clilornl, vcronnl, sulpliontil, urotbnno, phenncctinc, nnd mnny others. Lndividunlly cncli olio mag not bo sufficicntly iniportnnt to ivnrrnnt legislation nor chnngc of dcpnrtincntnl attitudo OF administration, b a t collcctively tlicsc, and otlicr puro clicmicnls not used in mcdicinc, mean tho organic fino clicmicnl industry.
Tlic us0 of duty-frco alcohol without iinduly Iinrnssing rcstrictions is cwcntinl for tho cstnl~lislimcnt of this branch of mrinufacturo,. with whicli goes progress in tho discovery and introduction of n c i ~ siibstaiices into nicdicino; but i t i3 3 widcr qucstion still, for this class of manufncturo is onc brnnch of tho fino clicmicnl industry whicli must bo considcrcd as n wholc. Tlic importnnco to tho country of estnblishing upon n firm basis tho fino chcmicnl industry, in wl~ich prorious to August, 1914, Gcrninny stood siiprcmo, has bccn argued 60 freqncntly nnd so convincingly during tho pnst six p a r s t1i:it furthcr rcfcrcnco to i t oiight t o bo unncccssnry, pot un11:i~pily this is not tho cnso. Now, bcforo tho in irstry is siifficicntly vtrong to resist thc onslnuglit, i t is cxposcd to attnck from nbrond by the urircstrictod iniportntion of foroign fino clicmicnh. As if to innko nssurnnco doubly suro, this infant industry is in proccss of being stri~nglcd nt birth by tho cxccss profits dnty.
Starred oj nlcoliol and stilled by tho E.P.D., whtrt rcmnins is being donc to death by tho Sanlrcy judgmont.
Among the papers rend nt tho Confcrencc mns ono by Alr. T. Tusting Cocking, who sho~vcd that whcn oil of eucnlyptiis and ortho-crcsol arc mixcd, hcnt is cvolred, and on cooling ivliito transpnrcnt crystals, consisting of nn cqu'iino~cculnr comt)in:rtion cf cincolc and ortlio-cresol, scpnrntc. This is R now compound, which has I m n nnincd ' I crcsincol." It may bo :ccrystnlliacd from various solvents, nnd forms 1,cnutiful prismatic crystals molting at 632O C., and boiling a t I s o C. Crcsincol is volntilc, nnd possosscs n plciisnnt cn~npl~ornccoue odour. It ie not caustic in ib3 iiction on tho skin, and yct contains 41 pcr ccnt. of crcsol. Hnving