The arotinoid Ro 40-8757 has antiproliferative effects in drug-resistant human colon and breast cancer cell lines in vitro

The effect of hypoxia on acquired drug r

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast-cancer cells in vitro

✍ R. Kalra; A-M. Jones; J. Kirk; G. E. Adams; I. J. Stratford 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 646 KB

## Abstract Prolonged hypoxia induced transient drug resistance in Chinese hamster lung fibroblasts. Previously hypoxic cells were resistant to adriamycin and resistant to etoposide. Complete recovery of etoposide sensitivity was observed following re‐aeration for 24 hr. A change in P‐glycoprotein