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The Arg16Gly polymorphism of the β2-adrenergic receptor and the natriuretic response to rapid saline infusion in humans

✍ Scribed by Eric M. Snyder; Stephen T. Turner; Michael J. Joyner; John H. Eisenach; Bruce D. Johnson

Book ID: 110113916
Publisher: Cambridge University Press
Year: 2006
Tongue: English
Weight: 399 KB
Volume: 574
Category: Article
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2006.107672

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The beta-2-adrenergic receptor (beta(2-)-AR) has several single-nucleotide polymorphisms. These influence the functional response to adrenergic stimulation; genotypes homozygous for Gly16-Glu27 or Gly16-Gln27 alleles (Gly16-Glu/Gln27 haplotypes) are associated with enhanced response, whereas genotyp