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The Application of Olefin Metathesis to the Synthesis of Biologically Active Macrocyclic Agents

✍ Scribed by Pierre Van de Weghe; Jacques Eustache


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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Ring-Closing Metathesis in the Synthesis
✍ Prashantβ€…H. Deshmukh; Carsten Schulz-Fademrecht; Panayiotisβ€…A. Procopiou; Davidβ€… πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 161 KB πŸ‘ 2 views

## Abstract Syntheses of novel 16‐membered macrocyclic peptidomimetics are reported, which employ iterative peptide coupling followed by high yielding ring‐closing metathesis (RCM) as the key cyclization step. The target macrocyclic compounds include examples containing a (2__S__)‐amino‐8‐oxodecano