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The application of nanoparticles in gene therapy and magnetic resonance imaging

✍ Scribed by Fernando Herranz; Elena Almarza; Ignacio Rodríguez; Beatriz Salinas; Yamilka Rosell; Manuel Desco; Jeff W. Bulte; Jesús Ruiz-Cabello

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
819 KB
Volume
74
Category
Article
ISSN
1059-910X

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✦ Synopsis

Abstract

The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application. © Microsc. Res. Tech., 2011. © 2011 Wiley‐Liss, Inc.

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