The application of EPR dosimetry for radiotherapy and radiation protection

✍ Scribed by R. Kudynski; J. Kudynska; H.A. Buckmaster

• Publisher: Elsevier Science
• Year: 1993
• Tongue: English
• Weight: 376 KB
• Volume: 44
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(93)90042-9

✦ Synopsis

This paper reports the first clinical trial of the application of the continuous wave electron paramagnetic resonance (CW-EPR) spectrum of alanine to determine the radiation dose received by a patient. The results of these measurements are compared with those obtained using thermoluminescent dosimetry (TLD) simultaneously.

The 9 GHz EPR measurements were made at 13°C. The time stability of the radiation induced radicals in alanine was confirmed. The fractionated radiation doses received in the clinical trial were determined from a calibration curve (linear regression coefficient r = 0.9995) obtained by irradiating L-alanine samples with 60-800 cGy doses using cobalt 60 gamma rays obtained from an Eldorado 8 Cobalt 60 unit at a rate of -6OcGy/min. It is shown that the absorbed dose in tissue-equivalent material can be determined using EPR spectroscopy with an accuracy of -3% at low dose levels (60cGy) whereas the error using TLD is -5% and that this method of dose determination is preferable to the present TLD method because it is simpler and more accurate.