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The apoptotic effect of interferon alpha in cultured rat hepatocytes

✍ Scribed by D. Karavelioǧlu; M. Gürsoy; E. Erdemli; R. Köksal; M. Turan; C. Baysal; S. Boyacioǧlu

Book ID
119526284
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
124 KB
Volume
32
Category
Article
ISSN
0168-8278

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The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora