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The apolipoprotein E gene and its age-specific effects on cognitive function

✍ Scribed by Fan Liu; Luba M. Pardo; Maaike Schuur; Pascual Sanchez-Juan; Aaron Isaacs; Kristel Sleegers; Ingrid de Koning; Irina V. Zorkoltseva; Tatiana I. Axenovich; Jacqueline C.M. Witteman; A. Cecile J.W. Janssens; John C. van Swieten; Yurii S. Aulchenko; Ben A. Oostra; Cornelia M. van Duijn


Book ID
116781414
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
114 KB
Volume
31
Category
Article
ISSN
0197-4580

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Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing)