We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4 cM for CYP2A-DM. These two markers
โฆ LIBER โฆ
The apolipoprotein CII gene: Subchromosomal localisation and linkage to the myotonic dystrophy locus
โ Scribed by D. J. Shaw; A. L. Meredith; M. Sarfarazi; S. M. Huson; J. D. Brook; O. Myklebost; P. S. Harper
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 282 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0340-6717
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Myotonic dystrophy is associated with disturbances in the insulin response, possibly due to an abnormality of the insulin receptor. Both the myotonic dystrophy (DM) and insulin receptor (INSR) genes are on chromosome 19. Using a cloned gene probe for INSR, we have studied its linkage relationships w