The antitumor complex ethylenediamine platinum (II) malonate: X-ray structure analysis, and studies of its stability in solution
โ Scribed by Shirley D. Cutbush; Reiko Kuroda; Stephen Neidle; A.Brian Robins
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 439 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0162-0134
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๐ SIMILAR VOLUMES
H-and 13C-NMR. data are reported for the complexes [Pt (1)Ll and [Pt (2)Ll; hexyl), DMSO, pyridine, secondary amine. The molecular structures of [Pt(2) (NHEt,)] (I) and [Pt (2)(PPh3)] (11) have been determined by X-ray analysis.
The development of a galenical formulation for poorly water soluble dichloroplatinum(I1) complexes suitable for the parenteral administration in cancer chemotherapy is described. The procedure, which we elaborated for [(+)-1,2-bis(4-fluorophenyI)ethyle- nediamine]dichloroplatinum(II) (rac-4F-PtClz),