The antiphosphorylcholine plaque-forming cell responses induced by the nematodeTrichinellain BWF1 mice

✍ Scribed by F. M. Ubeira; J. Leiro; R. Seoane; B. J. Regueiro

• Book ID: 104658753
• Publisher: Springer-Verlag
• Year: 1987
• Tongue: English
• Weight: 414 KB
• Volume: 176
• Category: Article
• ISSN: 0300-8584
• DOI: 10.1007/bf00193895

✦ Synopsis

We have tested the ability of the nematode Tricbinetla to infect young and old (NZB x NZW) F 1 (BWF1) mice. We report the capacity of these mice to respond to the parasite antigens containing the epitope phosphorylcholine. The values obtained in adult worm intestinal retention rates and in the number of encysted larvae on the 35th day postinfection showed that the old BWF1 mice are more susceptible than young BWF1 and control (BALB/c x CBA/j)F 1 (BCF1) mice to Tricbinella infection. However, unlike the BCF1 mice, young BWF1 mice were unable to produce a good anti-phosphorylcholine plaqueforming cell response after the killing of Tricbinella larvae by the anthelminthic mebendazole. Old BWF1 mice presented a discrete response which is discussed. Finally, our results seem to indicate that the lack of anti-phosphorylcholine response in young BWF 1 mice after mebendazole treatment may be related to the high susceptibility of these mice to the suppressive properties of encysted Tricbinella larvae against their own antigens.