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The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation

โœ Scribed by Helen Wiseman; Miranda J. Laughton; Henry R.V. Arnstein; Michael Cannon; Barry Halliwell

Book ID
115924164
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
327 KB
Volume
263
Category
Article
ISSN
0014-5793

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## Abstract Tamoxifen (TAM) is a nonsteroidal triphenylethylene antiestrogenic drug widely used in the treatment and prevention of breast cancer. TAM brings about a collapse of the mitochondrial membrane potential. It acts both as an uncoupling agent and as a powerful inhibitor of mitochondrial ele