The antihyperglycaemic blend effect of traditional Chinese medicine Byakko-ka-ninjin-to on alloxan and diabetic KK-CAy mice
✍ Scribed by Ikuko Kimura; Noboru Nakashima; Yoshitaka Sugihara; Chen Fu-jun; Masayasu Kimura
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 63 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The antihyperglycaemic interaction (blend effect) of component crude drugs included in a traditional Chinese prescription, Byakko-ka-ninjin-to (BN; consisted of five crude drugs, ginseng, anemarrhena, licorice, gypsum and rice) was investigated using genetically obese diabetic KK-CA y mice and alloxandiabetic mice. The water extract of ginseng, anemarrhena, licorice and gypsum when individually tested markedly lowered blood glucose levels in diabetic animals. Antihyperglycaemic effects of ginseng-anemarrhena and ginseng-licorice combinations were decreased compared with the respective individual effects. Such decreased effects were partially reversed by adding gypsum or by substituting CaCl 2 for gypsum. The combination of D-O-ANa and glycyrrhizin, respectively the main constituents from ginseng and licorice, also demonstrated a decreased effect compared with the respective individual effects. The CaCl 2 at 0.5 mg/kg (i.p.) was sufficient to partially reverse these effects. These results indicate that antihyperglycaemic effects of BN depend on four crude drugs and Ca 2 in the blend.