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The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes

โœ Scribed by George P Thomas; Morris Karmazyn; Andrew C Zygmunt; Charles Antzelevitch; Njanoor Narayanan


Book ID
110004225
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
107 KB
Volume
126
Category
Article
ISSN
0007-1188

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The positive inotropic effects of thyroid hormone in the heart, increased force and velocity of contraction have been mostly attributed to modulation of myosin ATPase isoenzymes (V1, V2 and V3), and sarcoplasmic reticulum Ca2+ pumping activity. In addition, we have suggested that the effects on vent