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The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice

✍ Scribed by Astrid G. Chapman; Stuart E. Smith; Brian S. Meldrum

Book ID
108022799
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
346 KB
Volume
9
Category
Article
ISSN
0920-1211

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A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats. GYKI 52466, 10 mg/kg given i.p. 5 min prior to electrical stimulation in