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The anticonvulsant effect of carbonic anhydrase inhibitors in mice — A noradrenergic mechanism of action

✍ Scribed by Mary Lou Torchiana; Victor J. Lotti; Clement A. Stone

Book ID
118321251
Publisher
Elsevier Science
Year
1973
Tongue
English
Weight
518 KB
Volume
21
Category
Article
ISSN
0014-2999

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## Abstract The tumor‐associated carbonic anhydrase (CA, EC 4.2.1.1) isozyme CA IX is highly overexpressed in many cancer types via the hypoxia inducible factor‐1α (HIF‐1α) cascade. Hypoxic tumors expressing CA IX show a poor response to classical chemo‐ and radio‐therapy treatments. CA IX signific