โ Scribed by F. K. Okwusasaba; S. C. Das; C. O. Isichei; M. M. Ekwenchi; O. Onoryvwe; A. O. Olayinka; V. E. Uguru; S. J. Dafur; E. O. Ekwere; O. Parry
No coin nor oath required. For personal study only.
The ether extract 18312-J of Ricinus communis seed (600 mg/kg and 1.2 g/kg) administered subcutaneously to rats possessed significant anticonceptive activity. The extract demonstrated an oestrogenic effect in immature ovariectomized rats and mice and was devoid of any antioestrogenic property. Furthermore, the extract did not induce a decidual response in oestrogen primed ovariectomized rats and did not inhibit deciduoma formation in rats treated with progesterone. Administration of 18312-J to rats significantly altered the activity profile of the uterine muscle with respect to the frequency and amplitude of contraction as well as decreased responsiveness to oxytocin, ergometrine, acetylcholine and transmural electrical stimulation (TNS, 1-20H z ). The anticonceptive effect of 18312-J may be due in part to a disturbance of the oestrogen/progesterone balance and as well as to a direct action on the uterus.
๐ SIMILAR VOLUMES
RICOM-1013-J (Ricinus communis var minor) administered orally once to each of 12 women volunteers at a dose of 2.5-2.7 g per 8 months, protected against pregnancy over a period of 7-8 months of study. A study of the effect of a contraceptive dose (20 mg/kg) on metabolic parameters in rat (food and w
The seed and petroleum ether fraction (PE; 5-20 mg/kg) of RICOM-1013-J demonstrated high antifertility efficacy in both animals and in women volunteers. Although PE demonstrated some oestrogenic activity in ovariectomized immature rats, there was no evidence of progestational activity. Administratio