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The Anticollagenolytic Potential of Lymecycline in the Long-Term Treatment of Reactive Arthritis

✍ Scribed by Anneli Lauhio; Timo Sorsa; Otso Lindy; Kimmo Suomalainen; Herkko Saari; Lorne M. Golub; YrjöT. Konttinen

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
350 KB
Volume
35
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA).

Methods. Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfate polyacrylamide gel electrophoresis.

Results. Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase.

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