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The anticoagulant activity of heparin: Measurement and relationship to chemical structure

โœ Scribed by T.W. Barrowcliffe; B. Mulloy; E.A. Johnson; D.P. Thomas


Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
717 KB
Volume
7
Category
Article
ISSN
0731-7085

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Synthesis of an N-Acetylated Heparin Pen
โœ Hans Peter Wessel; Ludvik Labler; Thomas B. Tschopp ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 714 KB

The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified