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The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients

โœ Scribed by Andersen, M H; Becker, J C; thor Straten, P

Book ID
110056144
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
87 KB
Volume
19
Category
Article
ISSN
0887-6924

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mcl-1 was identified as an "early-induction" gene that increases in expression during the differentiation of ML-1 human myeloblastic leukemia cells. The mcl-1 gene product proved to be a member of the bcl-2 gene family and, like bcl-2, to have the capacity to promote cell viability. The pattern of e