The anti-tumor effect of recombinant interferon alpha or gamma is influenced by tumor location

✍ Scribed by Michael J. Brunda; Viveca Sulich; Donna Bellantoni

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: French
• Weight: 348 KB
• Volume: 40
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910400617

✦ Synopsis

The in vivo anti-tumor effects of a recombinant human Recombinant inter$erons hybrid interferon alpha, rHuIFN-aAID, and recombinant mu-r ~u l ~~-a ~/ ~, a human hybrid recombinant interferon a]rine interferon gamma (rMulFN-y) were evaluated against the murine reticulum cell =rcoma M5076. The 2 interferons et al., 1983; Brunda and Rosenbaum, 1984; Brunda et al., were equally active in preventing experimental hepatic me-1984; Brunda and Wright, 1986), was prepared at Hoffmanntastases. However, the interferons differed in their relative La Roche. rMuIFN-y was kindly provided by Genentech, ability to influence the growth of the same tumor when treat-South San Francisco, CA (Gray and Goeddel, 1983). The ment was initiated following injection of tumor cells. Greater specific activities of IFNs ranged from 6-10 x 10' and 2-6 x efficacy was obtained in the treatment Of metastatic foci in 106 uimg protein for rHuIFN-aA/D and rMu1FN-y respecin the therapy of an S.C. growing M5076 tumor. These results demonstrate that the same tumor growing at different sites vesicular stomatitis virus on murine L cells (Rubenstein et a[. , can have different relative sensitivities to IFN-a and IFN-y. experimental hepatic metastases and s.c. tumor growth of pha which is active on murine cells (Rehberg et al., 1982; Lee the liver with rHulFN-aA/D, while rMu1FN-y Was more active tively, as assayed by inhibition of the cytopathic kffect of