𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The anti-EGFR monoclonal antibody blocks cisplatin-induced activation of EGFR signaling mediated by HB-EGF

✍ Scribed by Takeshi Yoshida; Isamu Okamoto; Tsutomu Iwasa; Masahiro Fukuoka; Kazuhiko Nakagawa

Book ID
113621094
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
613 KB
Volume
582
Category
Article
ISSN
0014-5793

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Anti-EGFR monoclonal antibodies which ac
Anti-EGFR monoclonal antibodies which act as EGF, TGFα, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours
✍ Helmout Modjtahedi; Toshi Komurasaki; Hitoshi Toyoda; Christopher Dean 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 294 KB

Epiregulin is the newest member of the epidermal growth factor (EGF) family of ligands that was isolated from conditioned medium of the murine fibroblast-derived tumour cell line NIH3T3/T7. Here, using a panel of anti-EGFR receptor (EGFR) monoclonal antibodies (MAbs) directed against 4 distinct epit

Anti-tumor activity of the combination o
Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases
✍ Maria Pia Morelli; Tina Cascone; Teresa Troiani; Concetta Tuccillo; Roberto Bian 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB

## Abstract Purpose: The epidermal growth factor receptor (EGFR) autocrine pathway plays an important role in cancer cell growth. Vascular endothelial growth factor A (VEGF‐A) is a key regulator of tumor‐induced endothelial cell proliferation and vascular permeability. ZD6474 is an orally available

c-jun-NH2JNK mediates invasive potential
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway
✍ Mónica Cáceres; Nicolás Tobar; Javier Guerrero; Patricio C. Smith; Jorge Martíne 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

## Abstract In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB‐EGF depend on the activity of c‐jun amino‐terminal kinase (JNK) in human prostatic DU‐145 cells. These cells overexpress EGFR and produce a high amount of uPA. Treatment with

Suppression of EGF-induced tumor cell mi
Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling
✍ Yong Pil Hwang; Hyo Jeong Yun; Jae Ho Choi; Eun Hee Han; Hyung Gyun Kim; Gye Yon 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 395 KB

## Abstract **Scope:** Capsaicin is a cancer‐suppressing agent. The aim of our study was to determine the effect of capsaicin on tumor invasion and migration; the possible mechanisms involved in this inhibition were investigated in human fibrosarcoma cells. **Methods and results:** We employed inv