## Abstract ## BACKGROUND Although various mechanisms have been recognized as being associated with the development of resistance to imatinib mesylate in vitro and in clinical situations, their relative significance and contributions remain poorly understood, as is the sequence of events leading t
โฆ LIBER โฆ
The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells
โ Scribed by Atsuko Tanimura; Toshiaki Yujiri; Yoshinori Tanaka; Masayuki Hatanaka; Noriyuki Mitani; Yukinori Nakamura; Kazutoshi Mori; Yukio Tanizawa
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 564 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0145-2126
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The expression of c-abl, c-sis, c-myc and N-ras oncogenes was examined in 2 lymphoblastoid cell lines, one with Ph1 (PB-1049) and the other without Ph1 (LN-1049), both established from a patient with chronic myelogenous leukemia (CML), and in a Ph1-positive cell line (PB-1049-T) derived from a tumor