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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

✍ Scribed by Grossmann, M.


Book ID
111747675
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
516 KB
Volume
19
Category
Article
ISSN
0261-4189

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The anti-apoptotic activities of Rel and
✍ Grossmann, M. πŸ“‚ Article πŸ“… 2000 πŸ› Nature Publishing Group 🌐 English βš– 516 KB

Rel and RelA, individually dispensable for lymphopoiesis, serve unique functions in activated B and T cells. Here their combined roles in lymphocyte development were examined in chimeric mice repopulated with c-rel(-/-) rela(-/-) fetal liver hemopoietic stem cells. Mice engrafted with double-mutant