The ansamycin antibiotic actamycin is shown to contaiti the meZeus (2a) or (2b) and the ansa bridge segments (7), ( 8), 191 and 110) by spectroscopic and degradative studies in conjunction with deuteriwn labelzing.
โฆ LIBER โฆ
The ansamycin antibiotic actamycin. II. Determination of the structure using carbon-13 biosynthetic labelling
โ Scribed by I.A. McDonald; R.W. Rickards
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 180 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The structure of the ansamycin antibiotic actamycin is defined by analysis of biosynthetically 13C-enriched and natural abwxlance n.m.r. spectra, in conjunction with previous degradative evidence.
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Spectroscopic techniques have played an increasingly important role in the structure elucidation of the aminoglycoside antibiotics 1 during the past decade. Initially using mass spectrometry and more recently in combination