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The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel

✍ Scribed by Naoki Agata; Hiroko Nogi; Michael Bamberg; Michael Milhollen; Minying Pu; Steven Weitman; Surender Kharbanda; Donald Kufe


Book ID
105992328
Publisher
Springer
Year
2005
Tongue
English
Weight
312 KB
Volume
56
Category
Article
ISSN
0344-5704

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✍ Brunilde Gril; Michel Vidal; Franck Assayag; Marie-France Poupon; Wang-Qing Liu; πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 633 KB

## Abstract HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras‐dependent signaling induced by