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The AMPK-related kinase, Nuak2 is modulated by the activation process and regulates motility of hepatic stellate cells (HSC)

โœ Scribed by Guerra, C. Tosti; Caligiuri, A.; Provenzano, A.; Bertolani, C.; Rombouts, K.; Pinzani, M.; Marra, F.


Book ID
122118403
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
58 KB
Volume
46
Category
Article
ISSN
1590-8658

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Upon liver injury, hepatic stellate cells (HSC) show increased proliferation, motility, and extracellular matrix (ECM) production. The extracellular signal-regulated kinases (ERK) control different functions in a cell-specific manner. In this study, we evaluated the role of ERK activation in culture