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The aminopyrine breath test predicts the outcome of hepatic transplantation in pigs

✍ Scribed by Christian D. H. Oakland; Rosemary Hickman; John Terblanche

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
472 KB
Volume
9
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

The aminopyrine breath test has been performed on Day 1 and Day 7 in pigs following experimental liver allografting. The results show that at 24 hr after surgery there was a significant reduction in liver function in all animals as measured by the elimination rate constant of 14C02 in the breath. This was very profound in the group that died within 5 days (0.09 2 0.01 hr-') and was significantly different from the group that survived (0.16 2 0.01 hr-l). There appears to be a critical value of the elimination rate constant (= 0.12 hr-') which predicts death within 5 days. These results would justify a trial of the aminopyrine breath test in patients after liver transplantation.

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