The Alzheimer amyloid precursor is produced by type I astrocytes in glial cultures and displays a fibrillary distribution pattern

The Alzheimer's amyloid precursor protei

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

✍ F. Berkenbosch; L. M. Refolo; V. L. Friedrich Jr.; D. Casper; M. Blum; Dr. Nikol 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 972 KB

The production of P-amyloid precursor protein (PAPP) by primary mixed glial cell cultures from cerebral cortex of 2-3 day postnatal rats was examined by Northern and Western blotting and by immunocytochemistry. A single 3.5 kb PAPP RNA transcript was detected using probes recognizing all forms of PA