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The alternate respiratory pathway ofCandida albicans

✍ Scribed by Maxwell G. Shepherd; Chin Moi Chin; Patrick A. Sullivan

Publisher
Springer
Year
1978
Tongue
English
Weight
727 KB
Volume
116
Category
Article
ISSN
0302-8933

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✦ Synopsis

Candida albicans contains a cryptic cyanide a n d a n t i m y c i n A insensitive respiratory system. This alternate oxidase was f o u n d (i) at all growth rates from # = 0.05 to 0.26 in a chemostat culture and (ii) in both mycelial and yeast forms of the organism. Neither chloramphenicol nor cycloheximide prevented the expression of the alternate oxidase. Salicylh y d r o x a m i c acid was a potent inhibitor of the cyanide insensitive respiration. The respiration of m i t o c h o ndria grown in the presence of a n t i m y c i n A was n o t inhibited by cyanide or a n t i m y c i n A b u t was inhibited by salicylhydroxamic acid.

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