The Allenic Pauson−Khand Reaction in Synthesis
✍ Scribed by Benito Alcaide; Pedro Almendros
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 189 KB
- Volume
- 2004
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
This manuscript describes a silicon-tethered Pauson-Khand reaction and subsequent cleavage of the resulting vinyl silane to afford functionalized alkylidene cyclopentenones. Altering the reaction conditions affords a selective reaction with either p-bond of the allene.
The regioselectivity of the cobalt-mediated cocyclisation of alkynes with allenic hydrocarbons leading to 4-and 5-alkylidenecyclopentenones was shown to depend on the substitution pattern of both the acetylenic and allenic components. An initial pseudoaxial coordination of the allenic hydrocarbon ma
## Abstract The carbonyldicobalt‐mediated alkyne/allene/CO cocyclization gives 4‐alkylidenecyclopentenones as the major [2+2+1] cycloadducts. The regio‐ and stereoselectivities depend mainly on the substitution pattern of both the alkyne and the allenic moieties, which can be rationalized using the