## Abstract Marked variation in phenotypic expression among __BRCA1__ and __BRCA2__ mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the Cβterminus of the AIB1 protein (amplified
The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development
β Scribed by Zdenek Kleibl; Ondrej Havranek; Stanislav Kormunda; Jan Novotny; Lenka Foretova; Eva Machackova; Jana Soukupova; Marketa Janatova; Spiros Tavandzis; Petr Pohlreich
- Publisher
- Springer-Verlag
- Year
- 2010
- Tongue
- English
- Weight
- 280 KB
- Volume
- 137
- Category
- Article
- ISSN
- 1432-1335
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## Abstract Variation in the penetrance estimates for __BRCA1__ and __BRCA2__ mutation carriers suggests that other factors may modify cancer risk from specific mutations. One possible mechanism is an epigenetic effect of polymorphisms in other genes. Genes involved in hormonal signal transduction
## Abstract Insulinβlike growth factorβ1 (IGFβI), a potent mitogen, is hypothesized to influence breast cancer risk. In 3 previous studies, a polymorphism in the __IGFβ1__ gene (sequence repeat length) was associated with plasma IGFβI level. We evaluated prospectively the relationships among a (CA)