## Abstract Disease association studies often test large numbers of markers, and various methods have been proposed to correct for multiple testing. In this paper, we propose an admixture maximum likelihood approach that estimates both the proportion of associated single nucleotide polymorphisms (S
β¦ LIBER β¦
The admixture maximum likelihood test to test for association between rare variants and disease phenotypes
β Scribed by Jonathan P Tyrer, Qi Guo, Douglas F Easton, Paul DP Pharoah
- Book ID
- 120675208
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 198 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1471-2105
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## Abstract Genomeβwide association studies succeeded in finding genetic variants associated with various phenotypes, but a large portion of the predicted genetic contribution to many traits remains unknown. One plausible explanation is that some missing variation is due to rare variants. Latest se