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The adipokine leptin increases skeletal muscle mass and significantly alters skeletal muscle miRNA expression profile in aged mice

✍ Scribed by Mark W. Hamrick; Samuel Herberg; Phonepasong Arounleut; Hong-Zhi He; Austin Shiver; Rui-Qun Qi; Li Zhou; Carlos M. Isales; Qing-Sheng Mi

Book ID: 116300747
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 681 KB
Volume: 400
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.08.079

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## Abstract Both central and peripheral leptin administrations reduce body weight, food intake, and adiposity in __ob/ob__ mice. In this study we compared effects of intracerebroventricular (ICV) and subcutaneous (SC) administration of leptin on bone metabolism in the appendicular and axial skeleto