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The addition of continuous infusion 5-FU to preoperative radiation therapy increases tumor response, leading to increased sphincter preservation in locally advanced rectal cancer

✍ Scribed by Christopher H Crane; John M Skibber; Elisa H Birnbaum; Barry W Feig; Anurag K Singh; Marc E Delclos; Edward H Lin; James W Fleshman; Howard D Thames; Ira J Kodner; Mary Ann Lockett; Joel Picus; Thinh Phan; Anshu Chandra; Nora A Janjan; Thomas E Read; Robert J Myerson

Book ID: 108435200
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 69 KB
Volume: 57
Category: Article
ISSN: 0360-3016
DOI: 10.1016/s0360-3016(03)00532-7

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## Abstract ## BACKGROUND Although controversial, some believe that preoperative chemoradiation increases the use of sphincter‐preserving surgery in low rectal carcinoma patients. This article investigates the relationship between objective tumor response and sphincter preservation in low rectal c