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The acylating potential of .gamma.-lactam antibacterials: base hydrolysis of bicyclic pyrazolidinones

✍ Scribed by Indelicato, Joseph M.; Pasini, Carol E.

Book ID: 121882809
Publisher: American Chemical Society
Year: 1988
Tongue: English
Weight: 533 KB
Volume: 31
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00401a026

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Bicyclic pyrazolidinones, a new class of

Bicyclic pyrazolidinones, a new class of antibacterial agent based on the β-lactam model

✍ Louis N Jungheim; Sandra K Sigmund; Jack W Fisher 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 159 KB

## Summarv: Several bicyclic nvrazolidinones were svnthesized as Y-lactam analogs of the \_\_ S-lactam antibiotics. Two of these compounds exhibited in vitro antibacterial activity, and thus constitute a new class of antibacterial agents.