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The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific

✍ Scribed by Jane A. Plumb; Robert Milroyf; Stanley B. Kaye


Book ID
115781450
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
658 KB
Volume
39
Category
Article
ISSN
0006-2952

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## Abstract It has been previously demonstrated that human carcinomas express interleukin‐2 receptor (IL‐2R) Ξ±, Ξ², and Ξ³ chains. The Ξ² and Ξ³ chains of IL‐2R have intermediate binding affinity for IL‐2 and are responsible for the intracellular signaling cascades after IL‐2 stimulation. IL‐2RΞ± lacks