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The activity of pulmonary indoleamine 2,3-dioxygenase in rats and mice is not altered by oxygen exposure

✍ Scribed by Edye E. Groseclose; Lee Frank


Book ID
113263844
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
492 KB
Volume
705
Category
Article
ISSN
0167-4838

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## Abstract Indoleamine 2,3‐dioxygenase (IDO) is the rate‐limiting enzyme in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism. IDO is immunosuppressive and is induced by inflammation in macrophages and dendritic cells (DCs). Previous studies have shown the serum Kyn/Trp levels in patient