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The Activating Effect of Synovial Fluid and Washings of Synovial Membrane on Autologous Lymphocytes in Rheumatoid Arthritis

✍ Scribed by J. Sebʼnk; A. Talerman; H. W. Wouters; P. H. Lems

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
258 KB
Volume
20
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

The effect of synovial fluid and washings of synovial membrane on autologous lymphocytes from patients with rheumatoid arthritis and other diseases has been studied using a rapid method based upon the increase in intranuclear birefringence occurring in the early stages of lymphocyte activation. Retardation of polarized light indicating increased lymphocyte activation was seen in lymphocytes from patients with rheumatoid arthritis but not in lymphocytes from patients with other diseases.

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The antirheumatic effects of triptolide, a purified component derived from a Chinese herb, Tripterygium wilfordii Hook f. (TWH), was examined. Peripheral blood mononuclear cells (PBMC), T cells, or human synovial fibroblasts isolated from healthy controls or rheumatoid arthritis (RA) patients were c