The activated core approach to combinatorial chemistry: A selection of new core molecules

✍ Scribed by Kent E. Pryor; Gerald W. Shipps Jr.; David A. Skyler; Julius Rebek Jr.

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 998 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(98)00139-2

✦ Synopsis

Four new activated core molecules suitable for use in solution-phase combinatorial organic chemistry have been prepared. These molecules represent an attempt to further explore shape-space and increase the structural diversity of prepared libraries, as well as to incorporate recognition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies use, d to simplify complex libraries and build individual molecular species based on the cores are also provided.