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The action of thallium acetate on spontaneous transmitter release in the rat neuromuscular junction

✍ Scribed by Herbert Wiegand; Renos Papadopoulos; Michael Csicsaky; Ursula Krämer

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
427 KB
Volume
55
Category
Article
ISSN
0340-5761

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✦ Synopsis

Frequencies and amplitudes of miniature endplate potentials (MEPP's) were recorded from neuromuscular junctions of the rat phrenic nerve-diaphragm preparation in vitro. Superfusion of the preparations with Ringer solution containing thallium acetate (Tlac) gradually increased the frequency of MEPP's by a factor of 10 within 30 min (1 X 10(-3) mol/l Tlac) and 180 min (5 X 10(-4) mol/l Tlac), whereas the amplitude of MEPP's remained unchanged. Frequency of MEPP's fitted a Poisson-distribution which persisted during superfusion with Tl+-Ringer. Sub-MEPP amplitudes remained unaffected by the action of thallium. It is concluded that thallium interferes presynaptically with spontaneous transmitter release.

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