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The action of intestinal enzymes upon cellulose acetate phthalate and butyl stearate enteric-coated tablets††This paper is based on a thesis presented to the Graduate Council of the Massachusetts College of Pharmacy by Peter E. Masucci in partial fulfillment of the requirements for the degree of Master of Science in Pharmacy.

✍ Scribed by Bauer, Charles W. ;Masucci, Peter E.

Publisher: Elsevier
Year: 1948
Weight: 459 KB
Volume: 37
Category: Article
ISSN: 0095-9553
DOI: 10.1002/jps.3030370312

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✦ Synopsis

In considering.the disintegration of enteric coatings of tablets it is essential to differentiate between intestinal contents and intestinal secretions. Enteric-coated tablets disintegrate in the intestinal contents which are seldom, if ever, alkaline. The disintegration of cellulose acetate phthalate and butyl stearate is due to the hydrolytic effect of the intestinal esterases and not, as is commonly believed, upon the alkalinity of the intestines.

T IS generally agreed that more and more

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