The hormonally active form of vitamin D3, 1,25-dihydroxy vitamin D3 [1,25-(OH)2-D3; calcitriol], regulates the differentiation and proliferation of epidermal keratinocytes in vitro. MC 903 (calcipotriol) is a novel vitamin D3 analogue which is at least 100 times less potent than 1,25-(OH)-2-D3 in it
โฆ LIBER โฆ
The action of a novel vitamin D3analogue, OCT, on immunomodulatory function of keratinocytes and lymphocytes
โ Scribed by M. Komine; Y. Watabe; S. Shimaoka; F. Sato; K. Kake; H. Nishina; M. Ohtsuki; H. Nakagawa; K. Tamaki
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 259 KB
- Volume
- 291
- Category
- Article
- ISSN
- 0340-3696
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The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1